An Unbiased View of pkrrating
The interfacial residues are hugely conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements reveal the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations help a design exactly where activating RNA serves being a scaffold to bind various PKR monomers, raising the c